Platelet Rich Plasma (PRP)

Platelet Rich Plasma (PRP) provides an autologous, complex mixture of blood cells and platelets that can mediate healing by supplying growth factors, cytokines, chemokines, and other bioactive compounds. PRP is now widely used in regenerative medicine in areas such as orthopedic surgery to treat various conditions involving the joint, tendon, or ligament. More recently, injectable forms of PRP have been helpful in the management of muscle, tendon, and cartilage injuries.

The better the concentration, the better the chances for recovery.

GenesisCS PRP Outperforms the Competition
In a side by side independent comparison study, GenesisCS outperfornns the major competitors in both platelet and growth factor concentrations per mL.

Platelet Results

Not all PRP is the Same
PRP products differ both qualitatively & quantitatively. It is well documented that not all PRP is the same. Patients may experience varying outcomes with PRP applications. This can be attributed to the system used to prepare the PRP.

To get the best results, the PRP system must significantly concentrate the platelet growth factors in the treatment sample.

The Best PRP Composition

GenesisCS Component Concentrating System

Refined Processing of the Platelet Plasma Suspension
Pure PRPTM can only be attained with refined processing of the Platelet Plasma Suspension (PPS). A short soft spin of whole blood, in the Executive Series Centrifuge, quickly prepares the PPS for the final Pure PRPTM sample.

The process is completed in 8.5 minutes.

The Non Inflammatory Solution

GenesisCS Component Concentrating System

Pure PRP™
Platelet rich plasma point of care therapy has been perfected with Pure PRP™. Pure PRP™ offers all of the good and none of the bad. Pure PRP™ is a platelet rich plasma preparation that contains highly concentrated platelet growth factors with no red blood cells. Pure PRP™ is also unique because it is the only PRP system that can be processed with or without neutrophil granulocytes. The platelet and growth factor concentrations are 7 to 9 X baseline and the yields range from 80-98%. The collected PRP sample is 6mL from a 60mL sample of anticoagulated whole blood. Pure PRP™ is the absolute solution to meets all clinical demands. With the Pure PRP™, physicians can now offer true growth factor concentrates in a medium that is suitable for active wound repair.

GenesisCS Pure PRP™ Sample: 6 mL
Platelet Concentrations: 7-9 X Baseline
Platelet Yields: 80-959’0
RBC Yields: 0%
Neutrophil Granulocyte Yields: 0-1%

No Red Blood Cells (RBCs)
Pure PRP™ provide high concentrations of platelet & growth factors in a pure plasma suspension. It has a no red blood cells which increases PRP viscosity making it more difficult to inject. Red blood cells in PRP has also been reported to cause pain. With Pure PRP™ this risk is eliminated. It is the purest sample of platelet rich plasma available at the point of care.

Process with or without Neutrophil Granulocytes
The polymorphonuclear cell family (PMNs) includes the body’s most abundantly occurring granulocyte known as neutrophils [1][2][3]. These granulocytes, in abundant & sustained doses releases cytokines, which can amplify inflammatory reactions by several other cell types [4]. This inflammation is needed for active wound repair, but in some cases is undesirable. Pure PRP™ is the only PRP system that can be processed with or without neutrophil granulocytes, providing physicians with their choice of active components needed for the care of their patients.

  1. REFERENCES
    Witko-Sarsat,V; Rieu P, Descamps-Latscha B, Lesavre P, Halbwachs-Mecarelli L (2000). “Neutrophils: molecules,functions and pathophysiological aspects’: Lab Invest 80 (5): 61 7-53.
    doi:l0.1038Ilabinvest.3780067.PMlD 10830774.
  2. Klebanoff, SJ; Clark, RA (1978).The Neutrophil: Function and Clinical Disorders. ElsevierlNorth-Holland Amsterdam. ISBN 0444800204.
  3. Nathan, C (Mar 2006). “Neutrophils and immunity: challenges and opportunities’: Nature Reviews Immunology 6 (March): 173-82. doi:lO.l038/nri1785. ISSN 1474-1733.PMID 16498448
  4. EarT, McDonald PP (2008). “Cytokine generation, promoter activation, and oxidant-independent NF-kappaB activation in a transfectable human neutrophilic cellular model: BMC Immunol. 9:
    doi:l0.1186/1471-2172-9-14.PMC 2322942. PMlD 18405381

Platelet Rich Plasma (PRP) Simple Safe & Effective

GenesisCS Component Concentrating System

Active Displacement Disc Technology (ADDT)

Direct access to the platelet and bone marrow aspirate buffycoat layer in a closed system environment.

Two Sterile Barrier Entries

Only two sterile barrier entries are designed to reduce handling and improve sterility maintenance.

Full Swinging Bucket Centrifugation

Optimizes separation & enhances the buffycoat concentrate. Executive Series Centrifuge provides entire vertical to horizontal separation in a smooth and unhindered motion. There is no platelet slip phenomenon.

Soft Braking Technology

Soft braking technology controls the acceleration and deceleration to prevent the buffycoat from re-suspending into the plasma after separation.

 

Consistent Outcome Regardless of Hematocrit

With Active Displacement Disc Technology, the operator has the flexibility to access the buffycoat concentrate at any point of separation. The GenesisCS System is not volume-dependent or hematocrit-dependent. Physicians adore the versatility of GenesisCS and enjoy using a system that can respond to their specific needs.

Closed System Processing

GenesisCS is a closed system throughout. Trapping blood within a watertight, sealed environment maximizes the safety of the contents and ensures sterility throughout processing.

Bone Marrow Concentrate

GenesisCS Component Concentrating System

Premium Performance

GenesisCS Bone Marrow Concentrating System provides consistently high yields and concentrations in a closed system. Processing is simple, user friendly and completed in 10 minutes.

GenesisCS BMC cell concentrations and yields from 60 mL bone marrow aspirate and in mL bone marrow concentrate sample: Total nucleated cells (TNC), Platelets (Plt) and CD34+ hematopoietic stem cells (HSC), n=4.

Concentrations

Yields

Preliminary Analysis of GenesisCS: Human Bone Marrow Concentration. Bioscience Research Associates, Inc.